Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• investigated for antioxidant activities. Singh et al. investigated the effect of the Mn3+/Mn2+ ratio on CAT activity [33]. Oxidizing Mn3O4 with NaIO4 yielded a high Mn3+/Mn2+ ratio and enhanced CAT activity compared with that of non-oxidized Mn3O4. Ten different iron oxide-based nanoantioxidants including 6

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• also includes cancer imaging and diagnosis such as the MRI imaging agent Resovist, carboxydextran-coated superparamagnetic iron oxide nanoparticles approved for liver contrast-enhanced MRI102 [87]. Another 10% are nanocrystals, such as Tricor (approved in 2004) or Triglide (approved in 2005), used to

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• photothermal therapy on a single platform has been developed in the form of vinorelbine-loaded polydopamine-coated iron oxide nanoparticles. Vinorelbine (VNB) is loaded on the surface of iron oxide nanoparticles produced by a solvothermal technique after coating with polydopamine (PDA) with varying weight

• , magnetic response, and controlled drug release with photothermal effect brings a different perspective to advanced cancer treatment research. Keywords: drug efficacy; iron oxide nanoparticles; photothermal; solvothermal method; Introduction Cancer is a widespread condition characterized by the

• , as they increase permeability and retention effect in solid tumors, enabling precise application to the targeted cells. Various structures such as silica-based conjugates, inorganic polymers, ceramic nanomaterials, gold, iron oxide, and noble metal nanoparticles have been utilized [9][10]. Among the

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan-Thang Cao,
• Vy Tran-Anh and
• Hieu Vu Quang

Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17

• nanocarrier that can be loaded with the chemotherapeutic medication chlorambucil and magnetic resonance imaging agents (e.g., iron oxide nanoparticles and near-infrared fluorophore IR780) for theragnostics. Poly(lactic-co-glycolic acid) was combined with the aforementioned ingredients to generate poly(vinyl

• alcohol)-based nanoparticles (NPs) using the single emulsion technique. Then the NPs were coated with F127 and F127-folate by simple incubation for five days. The nanoparticles have the hydrodynamic size of approx. 250 nm with negative charge. Similar to chlorambucil and IR780, iron oxide loadings were

• of these systems to serve as medication and imaging agent carriers for cancer treatment and diagnostics, respectively. Keywords: cancer; chlorambucil; F127-folate; IR780; iron oxide nanoparticles; PLGA; theragnostics; Introduction Theragnostic nanoparticles (NPs) are a diagnostic and therapeutic

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• , iron oxide, and mesoporous silica nanoparticles) [4]. Additionally, nanocarrier-free systems, such as drug nanocrystals, are also used to improve the delivery of poorly soluble drugs [5][6]. In our previous study, the saturation concentration of BBR in water was 2.0 mg/mL, while BBR nanoparticles

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• , iron oxide nanoparticles are the most prominent ones because of their biocompatibility, low toxicity, ease of synthesis, and high photothermal conversion efficiency. The influence of a magnetic field can also increase temperature generation by such nanoparticles, which is called magnetic hyperthermia

• . Since iron oxide nanoparticles absorb in the NIR region, irradiating them with a proper source will produce heat, which makes them suitable for theranostic purposes [32][42][43]. Carbon nanomaterials: Carbon-based materials have been identified as promising candidates for photothermal applications

• a low-power laser source. In a multimodal system of gold, iron oxide, and graphene oxide (GO) nanoparticles, the photothermal properties of graphene, the magnetic properties of iron oxide, and the surface plasmon resonance of gold enable multiple functions in a single system. The presence of gold

Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes

• Brunno R. F. Verçoza,
• Robson R. Bernardo,
• Luiz Augusto S. de Oliveira and
• Juliany C. F. Rodrigues

Beilstein J. Nanotechnol. 2023, 14, 893–903, doi:10.3762/bjnano.14.73

• The main goal of this work was to evaluate the therapeutic potential of green superparamagnetic iron oxide nanoparticles (SPIONs) produced with coconut water for treating cutaneous leishmaniasis caused by Leishmania amazonensis. Optical and electron microscopy techniques were used to evaluate the

• effort on the search for new treatments for different diseases. Its main objective is to develop therapies with higher specificity, effectiveness, and safety, as well as less toxicity [6]. One interesting class of nanomaterials in medicine are superparamagnetic iron oxide nanoparticles (SPIONs). SPIONs

• . It is the first time that superparamagnetic iron oxide nanoparticles SPIONs are observed inside the Leishmania spp and the parasitophorous vacuole. Chemical element mapping analysis by scanning electron microscopy confirmed the ferrous nature of the nanoparticle aggregates. These results prove the

Specific absorption rate of randomly oriented magnetic nanoparticles in a static magnetic field

• Ruslan A. Rytov and
• Nikolai A. Usov

Beilstein J. Nanotechnol. 2023, 14, 485–493, doi:10.3762/bjnano.14.39

• simulations using the stochastic Landau–Lifshitz equation are performed to study magnetization dynamics of dilute assemblies of iron oxide nanoparticles exposed to an alternating (ac) magnetic field with an amplitude Hac = 200 Oe and a frequency f = 300 kHz and a static (dc) magnetic field in the range Hdc

• of non-interacting magnetic nanoparticles of iron oxide is considered in a wide range of particle diameters, D = 18–50 nm. The SAR of the assembly is calculated depending on the amplitude and direction of the dc magnetic field in the range Hdc = 0–800 Oe. The spatial distribution of the assembly SAR

• paper, numerical simulations of the stochastic Landau–Lifshitz equation are used to study the dynamics of magnetization in dilute, randomly oriented assemblies of iron oxide nanoparticles under the combined action of ac and dc magnetic fields. It is shown that for nanoparticles with a diameter D < 25 nm

Mixed oxides with corundum-type structure obtained from recycling can seals as paint pigments: color stability

• Dienifer F. L. Horsth,
• Julia de O. Primo,
• Nayara Balaba,
• Fauze J. Anaissi and
• Carla Bittencourt

Beilstein J. Nanotechnol. 2023, 14, 467–477, doi:10.3762/bjnano.14.37

• atmospheres than organic pigments [12]. In addition, inorganic pigments offer the advantage of lower production cost [12] when using recycling materials as a precursor. Global demand for pigments was around 12 million tons in 2020 and is dominated by titanium dioxide white pigment [11]. However, iron oxide

• to use chromium as a coloring ion to obtain the same color result, without using toxic precursors. Remarkably, iron oxide red belongs to the class of yellow, red, and brown ocher, whose color depends on the crystallographic phase [11]. The hematite phase (α-Fe2O3) is the most stable, and its shade

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• oxidation, which leads to a decrease in heating efficiency [100]. In addition, magnetic NPs are usually recognized and cleared from the body, which prevents them from reaching their target [101]. Biomimetic cancer cell membrane technology can enhance the performance of magnetic iron oxide NPs (e.g., prevent

• oxidation, improve biocompatibility, enhance colloidal stability, and enhance targeting), enabling the ablation of tumor tissues by thermal energy [79]. MDA-MB-231 cell membrane-coated NPs loaded with superparamagnetic iron oxide nanoparticles (SPIONs) and PTX were designed for the combination treatment of

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• , gold nanoshells, and microbots) and imaging contrast nanoparticles (quantum dots and iron oxide), after homing into the tumor environment [113]. Xu et al. described an injectable nanoparticle generator (iNPG) showing substantial natural tumor tropism designed as aminopropyltriethoxysilane (APTES

Two-step single-reactor synthesis of oleic acid- or undecylenic acid-stabilized magnetic nanoparticles by thermal decomposition

• Mykhailo Nahorniak,
• Pamela Pasetto,
• Jean-Marc Greneche,
• Volodymyr Samaryk,
• Sandy Auguste,
• Anthony Rousseau,
• Nataliya Nosova and
• Serhii Varvarenko

Beilstein J. Nanotechnol. 2023, 14, 11–22, doi:10.3762/bjnano.14.2

• . Keywords: Fe(III) acetylacetonate; iron oxide nanoparticles; maghemite; magnetic nanoparticles; magnetite; thermal decomposition synthesis; Introduction Magnetic nanoparticles are increasingly being used in various fields thanks to the recent progress in their controlled synthesis and knowledge of their

• chemical and physical properties. One such area is biomedicine [1]. Especially iron oxide-based nanoparticles, due to their biodegradation, low toxicity, and enhanced oxidative resistance compared to metallic nanoparticles, show high potential in biomedical applications [2][3][4]. Up to now, iron oxide

• , studying the morphology and phase composition of iron-oxide-based nanoparticles is a critical issue. Nevertheless, magnetite and maghemite particles remain the most commonly used nanoparticles in biomedical applications. However, it must be noted that magnetite nanoparticles undergo rapid oxidation in air

Recent advances in nanoarchitectures of monocrystalline coordination polymers through confined assembly

• Lingling Xia,
• Qinyue Wang and
• Ming Hu

Beilstein J. Nanotechnol. 2022, 13, 763–777, doi:10.3762/bjnano.13.67

• ][38]. The networks can also help to take other components into the single crystals. Nanoparticles, such as quantum dots or iron oxide, which attach to the networks, can be encapsulated within the networks inside the single crystals, rendering the single crystals fluorescent or magnetic [39][40][41

A new method for obtaining the magnetic shape anisotropy directly from electron tomography images

• Cristian Radu,
• Ioana D. Vlaicu and
• Andrei C. Kuncser

Beilstein J. Nanotechnol. 2022, 13, 590–598, doi:10.3762/bjnano.13.51

• software. Regarding this, a test data volume filled with ellipsoids has been generated (Figure 3). Again, size, shape, position, and orientation of the ellipsoids have a Gaussian distribution in space, this time without the constraint of no overlap. Experimentally obtained system A system of iron oxide

Photothermal ablation of murine melanomas by Fe₃O₄ nanoparticle clusters

• Xue Wang,
• Lili Xuan and
• Ying Pan

Beilstein J. Nanotechnol. 2022, 13, 255–264, doi:10.3762/bjnano.13.20

• , whereas exposure to and subsequent absorption of NIR light by iron oxide nanoparticles promotes NIR-induced hyperthermia [10]. Although magnetic hyperthermia has been widely used in biomedical research, it is subject to several limitations such as the need for sophisticated equipment, cellular confinement

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• many years, titania has been employed as a colorant in food, cosmetics, and sunscreen. Moreover, Ti-containing metal alloys have been widely utilized in medical fields, because the have a higher biocompatibility than other vastly explored metal oxides such as silica, manganese oxide, and iron oxide

Thermal oxidation process on Si(113)-(3 × 2) investigated using high-temperature scanning tunneling microscopy

• Hiroya Tanaka,
• Shinya Ohno,
• Kazushi Miki and
• Masatoshi Tanaka

Beilstein J. Nanotechnol. 2022, 13, 172–181, doi:10.3762/bjnano.13.12

• experimental challenge toward elucidating the dynamic processes in oxidation. For example, the formation processes of iron oxide nanoparticles have been studied in detail using state-of-the-art X-ray scattering methods [4]. As a complementary method, variable-temperature scanning tunneling microscopy (VT-STM

Theranostic potential of self-luminescent branched polyethyleneimine-coated superparamagnetic iron oxide nanoparticles

• Rouhollah Khodadust,
• Ozlem Unal and
• Havva Yagci Acar

Beilstein J. Nanotechnol. 2022, 13, 82–95, doi:10.3762/bjnano.13.6

• luminescent polymer. Therefore, it is usually tagged with an organic fluorophore to be optically tracked. Recently, we developed branched PEI (bPEI) superparamagnetic iron oxide nanoparticles (SPION@bPEI) with blue luminescence 1200 times stronger than that of bPEI without a traditional fluorophore, due to

• sodium; superparamagnetic iron oxide nanoparticles; Introduction Luminescent materials are of great interest in biotechnology and medicine since they can be utilized in sensors, labelling, and imaging [1][2][3][4][5]. Luminescent proteins, luminescent synthetic polymers, and quantum dots are the most

• theranostic nanomaterials, PAMAM and PEI were frequently coupled with superparamagnetic iron oxide nanoparticles (SPIONs) for drug/gene delivery combined with magnetic resonance imaging [31][32]. Usually, these systems were conjugated with other fluorescent tags for optical detection of nanoparticles in cells

Heating ability of elongated magnetic nanoparticles

• Elizaveta M. Gubanova,
• Nikolai A. Usov and
• Vladimir A. Oleinikov

Beilstein J. Nanotechnol. 2021, 12, 1404–1412, doi:10.3762/bjnano.12.104

• magnetic hyperthermia. Basically, iron oxide nanoparticles were studied [5][6][7][8][9][10] because of their low toxicity and high saturation magnetization, although nanoparticles of other chemical compositions, such as metallic iron nanoparticles [11][12][13], and various ferrites [14][15][16][17] were

• optimal diameters occurs, since with an increased value of Kef, the height of the reduced energy barrier changes rapidly with a relatively small change in the particle volume. Note that earlier [30] a similar behavior of SAR was revealed for dilute randomly oriented assemblies of spherical iron oxide

Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles

• Sadaf Mushtaq,
• Khuram Shahzad,
• Tariq Saeed,
• Anwar Ul-Hamid,
• Bilal Haider Abbasi,
• Nafees Ahmad,
• Waqas Khalid,
• Muhammad Atif,
• Zulqurnain Ali and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2021, 12, 1339–1364, doi:10.3762/bjnano.12.99

• magnetocrystalline anisotropy, high saturation magnetization, and coercivity even at room temperature as compared to others [15]. The substitution of metal cations M+ for cobalt, nickel, and zinc contributes to diverse magnetic properties, morphology, and size of iron oxide NPs [13][16] along with varied tissue

• anisotropy [17][26]. Moreover, zinc ferrite has a slightly increased coercivity than nickel ferrite and iron oxide due to the formation of a noncollinear ferrimagnetic structure [27]. From Table 3, cobalt ferrite has the best magnetic properties in terms of saturation magnetization and coercivity, followed

Identifying diverse metal oxide nanomaterials with lethal effects on embryonic zebrafish using machine learning

• Richard Liam Marchese Robinson,
• Haralambos Sarimveis,
• Philip Doganis,
• Xiaodong Jia,
• Marianna Kotzabasaki,
• Christiana Gousiadou,
• Stacey Lynn Harper and
• Terry Wilkins

Beilstein J. Nanotechnol. 2021, 12, 1297–1325, doi:10.3762/bjnano.12.97

• international research efforts, such as the European Union’s NanoSafety Cluster [4] and associated research projects, such as BIORIMA [5], which has proposed a risk management framework for nanomaterials used in advanced therapeutic medicinal products and medical devices [6]. Indeed, in 2008, an iron oxide ENM

Morphology-driven gas sensing by fabricated fractals: A review

• Vishal Kamathe and
• Rupali Nagar

Beilstein J. Nanotechnol. 2021, 12, 1187–1208, doi:10.3762/bjnano.12.88

• structure, and large surface area of fractal structure. Figure 12e–j shows the optical and photo response of ultra-porous TiO2. These structures were estimated to have a fractal dimension of 1.77. Iron oxide-based fractals Bailly et al. fabricated dendrites, cubes, rhombohedra, and spindle-shaped hematite α

pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

• Karishma Berta Cotta,
• Sarika Mehra and
• Rajdip Bandyopadhyaya

Beilstein J. Nanotechnol. 2021, 12, 1127–1139, doi:10.3762/bjnano.12.84

• deployment in drug delivery is contingent upon controlled drug loading and a desired release profile, with simultaneous biocompatibility and cellular targeting. Iron oxide nanoparticles (IONPs), being biocompatible, are used as drug carriers. However, to prevent aggregation of bare IONPs, they are coated

• imparts multiple benefits – improved IONP stability, enhanced drug coating, higher drug uptake in macrophages at reduced toxicity and slower drug release. Keywords: drug-nanoparticle interactions; drug uptake; intra-macrophage; iron oxide nanoparticles; norfloxacin; Introduction Nanoparticles have taken

• the center-stage in drug delivery applications, wherein they can improve drug pharmacokinetics and pharmacodynamics and may also increase drug accumulation in both animal cells and bacteria, proving beneficial to overcome drug resistance [1][2]. Iron oxide nanoparticles (IONPs), due to their

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• against cancer cells [126]. Curcumin-loaded MNP (94.2 µg/mg of nanoparticles) were assayed against MDA-MB-231 cells. They contained iron oxide and β-cyclodextrin and were coated with Pluronic F68 polymer (polyethylene oxide-co-polypropylene oxide-co-polyethylene oxide) with an average size of 9 nm

• superparamagnetic iron oxide nanoparticles functionalized with sodium dodecyl sulfate (SDS) and coated with chitosan (40–45 nm), were able to induce apoptosis (IC50 30 µg/mL) in HeLa (cervical cancer) cells by damaging the DNA and increasing caspase-3 [136]. Curcumin-loaded, pH-sensitive Janus magnetic mesoporous

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• ]. Various nanostructures have been developed for free radical generation under US irradiation. A novel nanostructure was constructed based on a BNN-type NO-releasing molecule and superparamagnetic iron oxide nanoparticles (SPION)-encapsulated mesoporous silica NPs (MSN) which could generate NO free radicals